Crystallization of Organic Compounds

In this post you can download Crystallization Of Organic Compounds An Industrial Perspective Wiley (2009) Hsien-Hsin Tung, Edward L. Paul, Michael Midler, James A. McCauley.

Crystallization is an important step in pharmaceutical manufacturing because most of the active pharmaceutical ingredients (APIs) are produced in solid form. Despite this, this topic is less part of the academic curriculum than other topics such as reflection, extraction, and reaction. Often, engineers will learn the development of the crystallization process and work through trial and error, and it is not surprising that the wheels are changed from time to time, despite the hard work and effort. In terms of resource usage, this method is really ineffective. Added to this weakness is the lack of a system for transferring knowledge and skills from previous efforts.

Over the years, one way to do this has been to use memos and storyboards. But notes are often task-specific. Therefore, it is not a small task to uncover technical knowledge and knowledge buried in various memos and reports. Combining a collection of relevant theories and examples in the literature to fill this gap seems to be a good method for conveying information about principles and recommended practices.

The idea of writing and crystallization to meet this need was first proposed in the mid-1990s. At that time, there were few books that talked about the development of crystals. These papers seem to emphasize solidity, and many of the examples involve crystals of inorganic compounds. In the last 10 years, many new books on crystallization have been published, providing fast and rich information for scientists and development engineers. Unfortunately, the practical aspects of crystallization in our work and real industrial examples have not been fully explained.

This book has two purposes. One is to support the understanding of the basic elements of crystallization and the effect of these elements on the development of crystal structure. The second is to help experts to solve problems using good examples of production under good preventive measures. This book begins with the basics of thermodynamics (chapters 2 and 3), crystal nucleation and growth kinetics (chapters 4), and structure and concentration (chapters 5 and 6).

The following chapters deal with crystallization processes: freezing (chapter 7), evaporation (chapter 8), antisolvent (chapter 9), reactions (chapter 10) and some cases of crystallization (chapter 11) . As shown, good industrial examples are given in each chapter. We would like to express our sincere gratitude to the late Omar Davidson for his tireless support during the preparation of this book. We would also like to thank our colleagues, Lou Crocker, Albert Epstein, Brian Johnson, Mamoud Kaba, Joe Kukura, Amar Mahajan, Jim Meyer, Russ Lander, Karen Larson, Chuck Orella, Cindy Starbuck, Jose Tabora and Mike Thien, those who have kindly spend their time reviewing the chapters of this book (and in many cases, more than that). Their suggestions greatly enriched the content of this book.

Needless to say, we are truly grateful to the couple and our family members for their understanding and support during the long preparation period. Our goal is to help the reader develop the process of crystallization. Matthew 12:33, "Either call the tree good and its fruit good, or declare the tree rotten and its fruit rotten, for a tree is known by its fruit .” We hope that you, as readers, will find this book useful for your work. If so, this will be the greatest reward for us.